General
Preferred name
SGC-AAK1-1
Synonyms
SGC AAK1 1 ()
P&D ID
PD076485
CAS
2247894-32-0
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes for Understudied Kinases
Chemical Probes.org
High-quality chemical probes
SGC Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].
PRICE 62
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION SGC AAK1 1 is a potent and selective inhibitor of adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor. It activates Wnt signaling. (BOC Sciences Bioactive Compounds)
DESCRIPTION SGC-AAK1-1, a potent and selective inhibitor of AAK1 (AP2-associated kinase 1), has an IC50 of 270 nM and a Ki of 9 nM, and serves as a chemical probe. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent NUDT5 inhibitor (Tocris Bioactive Compound Library)
Compound Sets
13
BOC Sciences Bioactive Compounds
sgc-aak1-1-cas-2247894-32-0-291309
Cayman Chemical Bioactives
41118
Chemical Probes for Understudied Kinases
Chemical Probes.org
sgc-aak1-1
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
CZ-OPENSCREEN Bioactive Library
EUbOPEN Chemogenomics Library
EUB0000165
High-quality chemical probes
PD076485
Kinase Chemogenomic Set (KCGS)
SGC-AAK1-1
MedChem Express Bioactive Compound Library
HY-123940
SGC Probes
SGC-AAK1-1
TargetMol Bioactive Compound Library
T12885
Tocris Bioactive Compound Library
6528
External IDs
6
Properties
(calculated by RDKit )
Molecular Weight
427.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
3.58
TPSA
107.19
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Neuronal Signaling
Stem Cell/Wnt
Primary Target
Other Kinases
MOA
Inhibitor
Target
AAK1, RIOK1, BMP2K
AAK1
BIKE
Wnt
AAK1, BMP2K
BMP2K
AAK1 (AP2 associated kinase 1)
Control
SGC-AAK1-1N
CANSAR3153834
Protein Family
Kinase
Target class
Kinase, Kinase
Target subclass
Ser/Thr kinase, Ser/Thr kinase
Recommended Cell Concentration
1 uM
Source data